Análise Histopatológica e Imunoistoquímica da β-catenina e a e-caderina nas Doenças Inflamatórias Intestinais
DOI:
https://doi.org/10.55892/jrg.v7i15.1760Palavras-chave:
Doença inflamatória intestinal, Histopatologia, Colágeno, Imunoistoquímica, β-catenina, e-caderinaResumo
O aumento da remodelação da MEC constitui uma importante característica das DII. A resposta inflamatória excessiva e prolongada que ocorre no tecido intestinal é causa de alterações progressivas na arquitetura tecidual dos portadores de DC e RCU. O presente estudo a avaliação histopatológica e morfométrica da matriz extracelular nas doenças inflamatórias intestinais, bem como, estabelecer o perfil de imunoexpressão da β-catenina e e-caderina em amostras teciduais de pacientes com doença de Crohn e retocolite ulcerativa.
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ALARFAJ, Sumaiah J. et al. Mucosal genes expression in inflammatory bowel disease patients: new insights. Pharmaceuticals, v. 16, n. 2, p. 324, 2023.
BANDYOPADHYAY, Chirosree; SCHECTERSON, Leslayann; GUMBINER, Barry. P150 Enhancing epithelial barrier function with novel e-cadherin activating monoclonal antibodies reduces inflammatory bowel disease progression in mouse models. Gastroenterology, v. 158, n. 3, p. S47, 2020.
GILLILAND, Ashley et al. Pathobionts in inflammatory bowel disease: origins, underlying mechanisms, and implications for clinical care. Gastroenterology, v. 166, n. 1, p. 44-58, 2024.
GIUFFRIDA, Paolo; DI SABATINO, Antonio. Targeting T cells in inflammatory bowel disease. Pharmacological Research, v. 159, p. 105040, 2020.
HUNDORFEAN, Gheorghe; NEURATH, Markus F.; SITARU, Cassian. Autoimmunity against type VII collagen in inflammatory bowel disease. Journal of cellular and molecular medicine, v. 14, n. 10, p. 2393-2403, 2010.
HUSSEY, George S.; CRAMER, Madeline C.; BADYLAK, Stephen F. Extracellular matrix bioscaffolds for building gastrointestinal tissue. Cellular and molecular gastroenterology and hepatology, v. 5, n. 1, p. 1-13, 2018.
KIROV, Stefan et al. Degradation of the extracellular matrix is part of the pathology of ulcerative colitis. Molecular omics, v. 15, n. 1, p. 67-76, 2019.
KOELINK, Pim J. et al. Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease. Gut, v. 63, n. 4, p. 578-587, 2014.
KOUTROUBAKIS, I. E. et al. Serum laminin and collagen IV in inflammatory bowel disease. Journal of clinical pathology, v. 56, n. 11, p. 817-820, 2003.
LANGER, Victoria et al. IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed vascular barrier disruption. The Journal of clinical investigation, v. 129, n. 11, p. 4691-4707, 2019.
LU, Jiaxi et al. M1 Macrophage exosomes MiR‐21a‐5p aggravates inflammatory bowel disease through decreasing E‐cadherin and subsequent ILC2 activation. Journal of cellular and molecular medicine, v. 25, n. 6, p. 3041-3050, 2021.
MORTENSEN, J. H. et al. The intestinal tissue homeostasis–the role of extracellular matrix remodeling in inflammatory bowel disease. Expert review of gastroenterology & hepatology, v. 13, n. 10, p. 977-993, 2019.
ONFROY-ROY, Lauriane et al. Extracellular matrix mechanical properties and regulation of the intestinal stem cells: when mechanics control fate. Cells, v. 9, n. 12, p. 2629, 2020.
PARK, Ji Min et al. Inflammatory bowel disease-associated intestinal fibrosis. J Pathol Transl Med, v. 57, n. 1, p. 60, 2023.
PETERS, Lauren A. et al. A functional genomics predictive network model identifies regulators of inflammatory bowel disease. Nature genetics, v. 49, n. 10, p. 1437-1449, 2017.
PETREY, Aaron C.; CAROL, A. The extracellular matrix in IBD: a dynamic mediator of inflammation. Current opinion in gastroenterology, v. 33, n. 4, p. 234, 2017.
RODA, Giulia et al. Crohn’s disease. Nature Reviews Disease Primers, v. 6, n. 1, p. 1-19, 2020.
SCHLEGEL, Nicolas; BOERNER, Kevin; WASCHKE, Jens. Targeting desmosomal adhesion and signalling for intestinal barrier stabilization in inflammatory bowel diseases—Lessons from experimental models and patients. Acta physiologica, v. 231, n. 1, p. e13492, 2021.
SHENG, Yong Hua et al. A nucleotide analog prevents colitis-associated cancer via beta-catenin independently of inflammation and autophagy. Cellular and Molecular Gastroenterology and Hepatology, v. 11, n. 1, p. 33-53, 2021.
SINA, Christian; KEMPER, Claudia; DERER, Stefanie. The intestinal complement system in inflammatory bowel disease: Shaping intestinal barrier function. In: Seminars in immunology. Academic Press, 2018. p. 66-73.
STEWART, Daniel C. et al. Quantitative assessment of intestinal stiffness and associations with fibrosis in human inflammatory bowel disease. PLoS One, v. 13, n. 7, p. e0200377, 2018.
TAKU, Kobayashi et al. Ulcerative colitis (Primer). Nature Reviews: Disease Primers, v. 6, n. 1, 2020.
VILLANACCI, Vincenzo et al. Inflammatory Bowel Diseases: Does One Histological Score Fit All?. Diagnostics, v. 13, n. 12, p. 2112, 2023.
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