Zidovudine as a method to inhibitor HIV viral load in pregnant women living with the virus
DOI:
https://doi.org/10.55892/jrg.v7i15.1387Keywords:
Pregnant women, Zidovudine, HIVAbstract
Introduction: The Human Immunodeficiency Virus, known as HIV, is the causative agent of acquired immunodeficiency syndrome (AIDS), a condition that compromises the immune system, especially CD4+ T cells. The virus modifies the DNA of cells, promoting its replication. Objective: to carry out an analysis of the existing literature, aiming to map information about the benefits of using zidovudine as a method to inhibit viral load in pregnant women with HIV. Methodology: employs the scoping review protocol according to the guidelines outlined in the Joanna Briggs Institute evidence syntheses manual (2020), which incorporates the following steps: formulation of the research question, identification of relevant studies, selection of studies to be included, extraction of relevant data, consolidation, synthesis and presentation of results. Results and discussion: it showed that the use of zidovudine in the treatment of HIV infection in pregnant women was worrying due to the various toxic effects presented, such as mitochondrial dysfunction, bone marrow suppression and cardiac toxicity. Conclusion: Based on the studies analyzed, zidovudine demonstrated to be an effective tool when used in combination with other antiretroviral agents to reduce the HIV viral load in pregnant women, significantly contributing to the prevention of vertical transmission of the virus to newborns.
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ARKSEY, H; O'malley, L. Scoping studies: towards a methodological framework. International journal of social research methodology, v. 8, n. 1, p. 19-32, 2005. Disponível em: https://doi.org/10.1080/1364557032000119616. Acesso em: 28 mai. 2023.
AGUIAR, T. S. et al. Perfil epidemiológico do HIV/AIDS no Brasil baseado em dados do DataSUS no ano de 2021. Pesquisa, Sociedade e Desenvolvimento, [S. l.] , v. 3, pág. e4311326402, 2022. DOI: 10.33448/rsd-v11i3.26402. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/26402. Acesso em: 4 nov. 2023.
ASTAWESENG H, F. STULZ V, CONROY E, Tendências e efeitos da cobertura da terapia anti-retroviral durante a gravidez na transmissão do VIH de mãe para filho na África Subsariana. Evidências da análise de dados em painel. BMC. Disponivel em: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07119-6#auth-Virginia-Stulz-Aff3. Acesso em: 09 de Jan de 2024.
BRASIL, Ministério da Saúde., aids/hiv., disponível em: <https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/a/aids-hiv#:~:text=HIV%3A%20%C3%89%20um%20retrov%C3%ADrus%2C%20classificado,%C3%A9%20uma%20Infec%C3%A7%C3%A3o%20Sexualmente%20Transmi>. Acesso em: 04 de nov. de 2023.
BEITUNE, P. E. et al., O uso de anti-retrovirais em gestantes modifica o perfil lipídico? Rev. Bras. Ginecol. Obstet. Disponível: em:https://www.scielo.br/j/rbgo/a/k8tX3ggJJmsNvs6wCKGZtZH/?lang=pt#. Acesso em: 04 de nov. de 2023.
CENTRE F. E,B, M. Oxford Center for Evidence-based Medicine: levels of evidence. 2020. Disponível em: https://www.researchgate.net/figure/Levels-of-Evidence-Oxford-Centre-for-Evidence-based-Medicine-March-2009-107_tbl2_299412429. Acesso em: 21 jun. 2023.
CHI B, H, SEBIKARI D, BRUMMEL S, S. et al. Progesterone and prolactin levels in pregnant women living with HIV who delivered preterm and low birthweight infants: A nested case-control study. PLoS One. 2023 Jan 23;18(1):e0280730. doi: 10.1371/.0280730. journal.pone. Acesso em: 08 de fev de 2024.
CHAUHAN, N, DESAI M, SHAH S, SHAH A, GADHAVI R. Treatment outcome of different antiretroviral drug regimens in HIV-positive pregnant women. Perspect Clin Res. 2021 Jan-Mar;12(1):40-47. doi: 10.4103/picr.PICR_74_19. Epub 2020 May 7. PMID: 33816208; Acesso em: 4 nov. 2023.
FERNANDES, et al. Revisão sistematizada da literatura científica nacional ACERCA DA história do hiv/aids. Revista Brasileira de Sexualidade Humana, [S. l.], v. 32, n. 1, 2021. DOI: 10.35919/rbsh.v32i1.916. Disponível em: <https://www.rbsh.org.br/revista_sbrash/article/view/916>. Acesso em: 4 nov. 2023.
GALVÃO, T. F; Pansani, T. S. A; Harrad, D. Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epidemiologia e serviços de saúde, v. 24, p. 335-342, 2015.Disponível em:http://dx.doi.org/10.5123/S1679-49742015000200017. Acesso em: 28 mai. 2023.
HERNÁNDEZ-PINEDA J, Jung-Cook HH, Katende-Kyenda NL, et al. Assessment of lamivudine, zidovudine, lopinavir, and ritonavir plasma levels in HIV-positive pregnant women: Drug monitoring application to improve patient safety. Medicine (Baltimore). 2020 May 29;99(22):e20487. doi: 10.1097/MD.0000000000020487. PMID: 32481459.
HUNG T, C. LU L, C, LIN M, H. et al. Characteristics of HIV-positive pregnant women and HIV- and antiretroviral therapy-exposed fetuses: A case-control study. J Infect Dev Ctries. 2020 Aug 31;14(8):901-907. doi: 10.3855/jidc.11745. PMID: 32903235. Acesso em: 4 nov. 2023.
JOANNA BRIGGS INSTITUTE (JBI). Evidence Implementation Training Program. 2022. Disponível em:http://www.ee.usp.br/jbibrasil/cursos/evidence-implementation-training-program-eitp/. Acesso em: 28 mai. 2023.
KINAI E, NGUYEN H, D; T. DO HQ, et al. Influence of maternal use of tenofovir disoproxil fumarate or zidovudine in Vietnamese pregnant women with HIV on infant growth, renal function, and bone health. PLoS One. 2021 Apr 29;16(4):e0250828. doi: 10.1371/journal.pone.0250828. PMID: 33914827; PMCID: PMC8084453. Acesso em: 4 nov. 2023.
KIWEEWA F, M. TIERNEY C, BUTLER K, et al. Brief Report: Impact of Antiretroviral Regimen on Pregnancy and Infant Outcomes in Women With HIV/ HBV Coinfection. J Acquir Immune Defic Syndr. 2022 Sep 1;91(1):79-84. doi: 10.1097/QAI.0000000000003022. Epub 2022 May 27. PMID: 35621877; PMCID: PMC9377493. Acesso em: 4 nov. 2023.
LIN S, H. WANG Y, HARTLEY S, W. et al. Pediatric HIV/AIDS Cohort Study. In-utero exposure to zidovudine-containing antiretroviral therapy and clonal hematopoiesis in HIV-exposed uninfected newborns. AIDS. 2021 Aug 1;35(10):1525-1535. doi: 10.1097/QAD.0000000000002894. PMID: 33756513; PMCID: PMC8286286. Acesso em: 4 nov. 2023.
MENEGOTTO M, MAGDALENO A,M. Silva, C L et al. Transmissão vertical do HIV entre mulheres grávidas em uma cidade com as maiores taxas de HIV no Brasil. American Journal of perinatology. 10.1055/s-0040-1722605. Disponível em:https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0040-1722605#info. Acesso em: 11 de mar de 2024.
MOHER, D. et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of internal medicine, v. 151, n. 4, p. 264-269, 2009. Disponível em: https://doi.org/10.1016/j.ijsu.2010.02.007. Acesso em: 28 mai. 2023
PEARSON, A. et al. The JBI model of evidence‐based healthcare. International Journal of Evidence‐Based Healthcare, v. 3, n. 8, p. 207-215, 2005. Disponível em: https://doi.org/10.1111/j.1479-6988.2005.00026.x. Acesso em: 28 mai. 2023.
PETERS, M. D. J. et al. Updated methodological guidance for the conduct of scoping reviews. JBI evidence synthesis, v. 18, n. 10, p. 2119-2126, 2020. Disponível em:https://doi.org/10.11124/jbies-20-00167. Acesso em: 28 mai. 2023.
POLLOCK, D. et al. Undertaking a scoping review: A practical guide for nursing and midwifery students, clinicians, researchers, and academics. Journal of advanced nursing, v. 77, n. 4, p. 2102-2113, 2021. Disponível em:https://doi.org/10.1111/jan.14743. Acesso em: 28 mai. 2023.
SACKETT, D. L. et al. Evidence based medicine: what it is and what it isn't. Bmj, v. 312, n. 7023, p. 71-72, 1996. Disponível em:https://doi.org/10.1136/bmj.312.7023.71. Acesso em: 28 mai. 2023.
TRICCO, A. C. et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Annals of internal medicine, v. 169, n. 7, p. 467-473, 2018. Disponível em: https://doi.org/10.7326/M18-0850. Acesso em: 28 mai. 2023.
TUFANARU, C. et al. Fixed or random effects meta-analysis? Common methodological issues in systematic reviews of effectiveness. JBI Evidence Implementation, v. 13, n. 3, p. 196-207, 2015. Disponível em:https://doi.org/10.1097/xeb.0000000000000065. Acesso em: 28 mai. 2023.
TRAMASSO L. BOVIS F. BIAGIO D, A. et al. Uso intraparto de zidovudina em uma grande coorte de mulheres grávidas que vivem com HIV na Itália. Journal of Infection. Disponível em: https://www.journalofinfection.com/article/S0163-4453(22)00475-3/abstract#articleInformation. Acesso em: 08 de mar. de 2024.
TOBIN N, H. MURPHY A, L, I, F. et al. Study Team. Metabolomic profiling of preterm birth in pregnant women living with HIV. Metabolomics. 2023 Oct 25;19(11):91. doi: 10.1007/s11306-023-02055-1. PMID: 37880481; PMCID: PMC10600291. Acesso em: 4 nov. 2023.
PIACSEK, G. E. A morte assusta o sensacionalismo: O jornal Notícias Populares encara o fantasma do surgimento da AIDS. Revista Pluri Número Zero: Percursos, v. 1 n. 1 (2018);. doi: https://doi.org/10.26843/rpv112018p147-160. Disponível em: https://revistapluri.cruzeirodosulvirtual.com.br/index.php/pluri/article/view/41. Acesso em: 04 de nov. de 2023.
ROXBY A, C. YUHAS K, et al. Mycoplasma genitalium infection among HIV-infected pregnant African women and implications for mother-to-child transmission of HIV. AIDS. 2019 Nov 15;33(14):2211-2217. doi: 10.1097/QAD.0000000000002335. PMID: 31385863; PMCID: PMC6832839. Acesso em: 4 nov. 2023.
SILVA, L. T. C. et al., perfil epidemiológico de gestantes portadoras de hiv/aids no brasil., v 8.n 1.p 120-135. Revista Interdisciplinar em Saúde, Cajazeiras, 8 (único): 120-135, 2021. DOI: 10.35621/23587490.v 8.n 1.p 120-135. Disponível em: https://interdisciplinaremsaude.com.br/Volume_29/Trabalho_09_2021.pdf.
SILVA, C; M. et al., Panorama epidemiológico do HIV/AIDS em gestantes em um estado do Nordeste brasileiro., Rev. Brasileira. Enferm. 2018. Disponível em: https://www.scielo.br/j/reben/a/ztwvxH8Q5FBpqnQW6V6PCCH/#. Acesso em: 04 de nov. de 2023.
SILVA, I. S. et al. Terapêuticas que reduzem a transmissão vertical do HIV., Rev Soc Bras Clin Med. 2020. Disponível em:https://docs.bvsalud.org/biblioref/2022/03/1361476/120-124-1.pdf. Acesso em: 11 de out. de 2023.
SHAH, I. KATHWATE, J. Metabolic acidosis and encephalopathy in an HIV-exposed infant on breastfeeding and maternal antiretroviral therapy. Indian J Sex Transm Dis AIDS. 2020 Jan-Jun;41(1):122-124. doi: 10.4103/ijstd.IJSTD_83_16. Epub 2020 Jun 18. PMID: 33063000; PMCID: PMC7529180. Acesso em: 4 nov. 2023.
YAKUT, N. KEPENEKLI, E. Evaluation of infants with HIV-infected mothers and perinatal transmission in Turkey: A single-center experience. North Clin Istanb. 2021 May 24;8(3):243-248. doi: 10.14744/nci.2021.59013. Acesso em: 4 nov. 2023.
