Androgenetic alopecia treatments: an integrative study
DOI:
https://doi.org/10.55892/jrg.v7i15.1589Keywords:
Androgenetic Alopecia, Treatments for androgenetic alopecia, AGA, Hair loss, BaldnessAbstract
Introduction: AGA consists of a chronic inflammation that affects hair follicles and manifests when any of the phases of the hair development cycle is altered. The pathology is not painful, however, it can trigger physical problems resulting from the loss of eyelashes and eyelashes, as well as skin irritations. Objectives: to present the available treatments for androgenetic alopecia. Methodology: this is a bibliographic, descriptive, integrative review study of articles published between 2019 and 2024, in the MEDLINE, LILACS, SCIELO and BVS databases, published in Portuguese and English. The titles, abstracts and full text that answered the objective and guiding question were read, and their results were discussed and presented in tables. Results: it was evident that there is still no single and definitive treatment for AGA, however, the available treatments have demonstrated high satisfaction rates with regard to treatments for AGA. Conclusion: The study highlights the different treatments available for AGA and the importance of a good patient assessment so that the best treatment can be administered according to the needs of each patient.
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ABECK, F; HANSEN, I.; KÖTT, J.; et al. Patient‐reported outcomes of topical finasteride/minoxidil treatment for male androgenetic alopecia: A retrospective study using telemedical data. Journal of Cosmetic Dermatology, v. 23, n. 9, mai. 2024. DOI: https://doi.org/10.1111/jocd.16360.
AFZAL, G.; AHMED, N.; ZAHOOR, F.; et al. Efficacy of Platelet-Rich Plasma versus 5% Topical Monixidil for the Treatment of Androgenetic Alopecia. JCPSP | Journal of College of Physicians and Surgeons Pakistan. Jcpsp.pk. v. 34, n. 1, p. 11-15, jan. 2024. DOI: 10.29271/jcpsp.2024.01.11.
BLOCH, LD; ESCUDEIRO, CC. Avaliação da eficácia de ampola capilar contendo células-tronco do folículo piloso humano na redução da perda capilar em mulheres acometidas por alopecia androgenética. Surgical & Cosmetic Dermatology, v. 12, n. 1, 51-56p., jan. 2020.
GRESSENBERGER, P.; PREGARTNER, G.; GARY, T.; et al. Platelet-rich Plasma for Androgenetic Alopecia Treatment: A Randomized Placebo-controlled Pilot Study. Acta Dermato Venereologica, v. 100, n. 15, p. adv00247–adv00247, ago. 2020. DOI: 10.2340/00015555-3609.
KIELING, L.; KONZEN, A. T.; ZANELLA, R. K.; et al. O plasma autólogo rico em plaquetas é capaz de aumentar a densidade capilar em pacientes com alopecia androgenética? Revisão sistemática e metanálise de ensaios clínicos randomizados. Anais Brasileiros de Dermatologia, ago. 2022. DOI: 10.1016/j.abdp.2024.07.001.
KOZICKA, K.; ŁUKASIK, A.; MACIE, JP.; et al. Scalp vascularization as a marker of topical minoxidil treatment efficacy in patients with androgenetic alopecia. Advances in Dermatology and Allergology, v. 39, n. 2, p. 316–320, 2022. DOI: 10.5114/ada.2021.103301.
LIN, L.; MA, Q; LUO, W.; et al. Efficacy of type A botulinum toxin treatment for androgenetic alopecia using ultrasound combined with trichoscopy. Skin Research and Technology, v. 30, n. 6, jun. 2024. DOI: 10.1111/srt.13803.
LUEANGARUN, S.; PANCHAPRATEEP, R. An Herbal Extract Combination (Biochanin A, Acetyl tetrapeptide-3, and Ginseng Extracts) versus 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A 24-week, Prospective, Randomized, Triple-blind, Controlled Trial. The Journal of clinical and aesthetic dermatology, v. 13, n. 10, p. 32–37, jun. 2020.
LUEANGARUN, S.; TEMPARK, T. Novel Application of 1064-nm Picosecond Nd:YAG Laser for Male Androgenetic Alopecia Treatment. The Journal of clinical and aesthetic dermatology, v. 17, n. 1, p. 24–27, jan. 2024.
PAKHOMOVA, E. E ; SMIRNOVA, I. O. Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia. International Journal of Molecular Sciences, v. 21, n. 18, p. 6516–6516, sep. 2020. DOI: 10.3390/ijms21186516.
PAVITHRA, TR.; RAJASHEKAR, TS.; SURESH, KK; et al. A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma Therapy in the Treatment of Androgenetic Alopecia. Cureus, v. 15, n. 5, mai. 2023. DOI: 10.7759/cureus.38696.
QIU, J.; Yi, Y.; JIANG, L.; et al. Efficacy assessment for low-level laser therapy in the treatment of androgenetic alopecia: a real-world study on 1383 patients. Lasers in medical science, v. 37, n. 6, p. 2589–2594, 2022. DOI: 10.1007/s10103-022-03520-4.
QU, H.; ZHANG, R.; Xin, W.; et al. Investigator‐blinded, controlled, and randomized comparative study on 1565 nm non‐ablative fractional laser versus 5% minoxidil for treatment of androgenetic alopecia. Journal of Cosmetic Dermatology, v. 23, n. 5, p. 1638–1644, jan. 2024. DOI: https://doi.org/10.1111/jocd.16173.
QUIRINOP, L.; VILELA, GR. Coquetel de Fatores de Crescimento Incluindo Fator 9 de Crescimento de Fibroblastos (Cellcurin) Sérum no Tratamento da Alopecia Androgenética. BWS Journal (Descontinuada), v. 4, p. 1–12, 2021.
REYGAGNE, P.; MANDEL, VD.; DELVA, C.; et al. An anti‐hair loss treatment in the management of mild androgenetic alopecia: Results from a large, international observational study. Dermatologic Therapy, v. 34, n. 6, 2021. DOI: 10.1111/dth.15134.
SATTUR, S.; TALATHI, A.; SHETTY, G.; et al. Comparative Clinical Study Evaluating the Efficacy and Safety of Topical 5% Cetosomal Minoxidil and Topical 5% Alcohol-Based Minoxidil Solutions for the Treatment of Androgenetic Alopecia in Indian Men. Cureus, v. 15, n. 10, out. 2023. DOI: 10.7759/cureus.46568.
SEOUDY, WM.; METWALLY, OA.; ELFANGARY, M. M; et al. Assessment of efficacy of different botulinum toxin A concentrations in the treatment of androgenetic alopecia assessed by dermoscopy. Journal of Cosmetic Dermatology, v. 23, n. 2, p. 417–425, 2024. DOI: https://doi.org/10.1111/jocd.15972.
SHULIAN, W.; SHIZHAO, L.; CHEN, J; et al. Evaluation of platelet-rich plasma plus basic fibroblast growth factor combined with minoxidil in the treatment of androgenetic alopecia: A randomized controlled trial. Journal of Cosmetic Dermatology, v. 22, n. 7, p. 1995–2002, 2023. DOI: https://doi.org/10.1111/jocd.15825.
SORBELLINI, E.; FUSCO, I.; MADEDDU, F.; et al. Experience of Novelty Laser Therapy Emission with 675 nm Wavelength for the Treatment of Androgenetic Alopecia in Male and Female Patients: A Case Series Study. Photobiomodulation. Photomedicine and Laser Surgery, v. 41, n. 6, p. 265–271, 2023. DOI: doi.org/10.1089/photob.2022.0162.
SOUZA, MT; SILVA, MD; CARVALHO, L. Integrative review: what is it? How to do it? Einstein (São Paulo), v. 8, n. 1, p. 102–106, mar., 2010. DOI: https://doi.org/10.1590/S1679-45082010RW1134.
TRÜEB, RM. Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel (Hamamelis virginiana)-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia. International Journal of Trichology, v. 15, n. 3, p. 108–112, 2023. DOI: 10.4103/ijt.ijt_55_22.
WANG, S.; LI, D.; ZOU, M.; et al. Efficacy of autologous platelet-rich plasma combined with a non-cross-linked hyaluronic acid compound in the treatment of female androgenetic alopecia: A retrospective, case-series study. Journal of Cosmetic Dermatology, v. 22, n. 12, p. 3268–3275, 2023. DOI: https://doi.org/10.1111/jocd.15861.
WEI, W.; ZHANG, Y.; LONG, B.; et al. Injections of platelet‐rich plasma prepared by automatic blood cell separator combined with topical 5% minoxidil in the treatment of male androgenetic alopecia. Skin Research and Technology, v. 29, n. 7, 2023. DOI: https://doi.org/10.1111/srt.13315.
YEPURI, V. ;VENKATARAM, M. Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia: Study of Efficacy of the Treatment and the Number of Sessions Required. PubMed, v. 14, n. 2, p. 184–190, 2021. DOI: 10.4103/JCAS.JCAS_33_20.
YOON, JS.; KU, WY.; LEE, JH.; et al. Low-level light therapy using a helmet-type device for the treatment of androgenetic alopecia. Medicine, v. 99, n. 29, p. e21181–e21181, 2020. DOI: 10.1097/MD.0000000000021181.
ZHOU, Y.; YU, S.; ZHAO, J.; et al. Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia. BioMed Research International, v. 2020, p. 1–7, 2020. DOI: https://doi.org/10.1155/2020/1501893.
