Hyperbaric medicine as an adjunct treatment for fibromyalgia: an integrative review

Authors

DOI:

https://doi.org/10.55892/jrg.v9i20.3216

Keywords:

Fibromyalgia, Hyperbaric Oxygen Therapy, Chronic Pain, Quality of Life, Neuroplasticity

Abstract

Fibromyalgia is a chronic syndrome characterized by diffuse musculoskeletal pain, frequently associated with fatigue, sleep disorders, and cognitive impairment, with a significant impact on quality of life. Recent evidence suggests that mechanisms such as oxidative stress, mitochondrial dysfunction, and central sensitization play a relevant role in the pathophysiology of the disease. In this context, hyperbaric oxygen therapy has been investigated as a complementary therapeutic strategy due to its ability to increase tissue oxygenation and modulate inflammatory and neurobiological processes. This study aims to conduct an integrative literature review on the effects of hyperbaric oxygen therapy in the treatment of fibromyalgia. The search was conducted in the PubMed, SciELO, and BVS/LILACS databases, using descriptors related to fibromyalgia, hyperbaric oxygen therapy, chronic pain, and quality of life. 77 articles were identified, of which 12 met the inclusion criteria. The findings suggest that hyperbaric oxygen therapy is a promising approach in the adjunctive treatment of fibromyalgia, contributing to pain reduction, improved quality of life, decreased fatigue, and modulation of central pain mechanisms, such as neuroplasticity. However, further studies with more standardized methodology are needed to consolidate its effectiveness and define ideal treatment protocols.

Downloads

Download data is not yet available.

Author Biographies

Flávia Gabriela Tojal Hora, Universidade Tiradentes, SE, Brasil

Graduanda em Medicina pela Universidade Tiradentes (UNIT).

Fernanda Moura Barbosa, Universidade Tiradentes, SE, Brasil

Graduanda em Medicina pela Universidade Tiradentes (UNIT).

Bruno Barreto Cintra, Universidade Tiradentes, SE, Brasil

Graduado em Medicina pela Faculdade de Medicina de Marília; Residência em Cirurgia Geral e Cirurgia Plástica no Hospital Municipal Dr. Mário Gatti; Especialização em Microcirurgia Reconstrutiva no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo; Doutorado em Ciências Biomédicas pelo Instituto Universitário Italiano em Rosário, Argentina; Docente do curso de Medicina da Universidade Tiradentes.

References

EFRATI, S. et al. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome - prospective clinical trial. PLoS One, v. 10, n. 5, e0127012, 2015.

GINZARLY, Mouzayan et al. Efficacy of hyperbaric oxygen therapy in treating fibromyalgia linked to childhood trauma after late-onset and over a decade of symptoms: a case report. Journal of Medical Case Reports, v. 19, n. 1, p. 386, 2025. DOI: 10.1186/s13256-025-05453-2.

HADANNY, Amir et al. Hyperbaric oxygen therapy can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse: randomized controlled trial. Frontiers in Psychology, v. 9, p. 2495, 2018. DOI: 10.3389/fpsyg.2018.02495.

IZQUIERDO-ALVENTOSA, Ruth et al. Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial. Therapeutic Advances in Musculoskeletal Disease, v. 12, p. 1759720X20930493, 2020. DOI: 10.1177/1759720X20930493.

IZQUIERDO-ALVENTOSA, Ruth et al. Effects of a low-pressure hyperbaric oxygen therapy on psychological constructs related to pain and quality of life in women with fibromyalgia: a randomized clinical trial. Medicina Clínica, v. 162, n. 11, p. 516–522, 2024. DOI: 10.1016/j.medcli.2023.12.016.

BOUSSI-GROSS, Rachel et al. Hyperbaric oxygen therapy vs. pharmacological intervention in adults with fibromyalgia related to childhood sexual abuse: a prospective, randomized clinical trial. Scientific Reports, v. 14, n. 1, p. 11599, 2024. DOI: 10.1038/s41598-024-61141-2.

CHEN, Xinxin et al. Efficacy and safety of hyperbaric oxygen therapy for fibromyalgia: a systematic review and meta-analysis. BMJ Open, v. 13, n. 1, e062322, 2023. DOI: 10.1136/bmjopen-2022-062322.

CAO, Chunfeng et al. Effectiveness of hyperbaric oxygen for fibromyalgia: a meta-analysis of randomized controlled trials. Clinical Practice, v. 13, n. 3, p. 583–595, 2023. DOI: 10.3390/clinpract13030053.

ATZENI, Fabiola et al. Hyperbaric oxygen therapy in fibromyalgia and the diseases involving the central nervous system. Clinical and Experimental Rheumatology, v. 38, n. 1, suppl. 123, p. 94–98, 2020.

ASSAVARITTIRONG, Chanika; SAMBORSKI, Włodzimierz; GRYGIEL-GÓRNIAK, Bogna. Oxidative stress in fibromyalgia: from pathology to treatment. Oxidative Medicine and Cellular Longevity, v. 2022, p. 1582432, 2022. DOI: 10.1155/2022/1582432.

CASALE, Roberto et al. Neuromuscular efficiency in fibromyalgia is improved by hyperbaric oxygen therapy: looking inside muscles by means of surface electromyography. Clinical and Experimental Rheumatology, v. 37, suppl. 116, n. 1, p. 75–80, 2019.

BIN-ALAMER, O. et al. Hyperbaric oxygen therapy as a neuromodulatory technique: a review of the recent evidence. Frontiers in Neurology, v. 15, 9 out. 2024.

HAN, X. et al. Hyperbaric oxygen therapy for patients with fibromyalgia: a systematic review protocol. BMJ Open, v. 13, n. 6, p. e071092, jun. 2023.

EL-SHEWY, K. M. et al. Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review. Biomedicine & Pharmacotherapy, v. 109, p. 629–638, jan. 2019.

MOTA NETO, J. et al. Protocol of HOTFy: randomised clinical trial to hyperbaric oxygen therapy in fibromyalgia. BMJ open, v. 13, n. 1, p. e069153, dez. 2023.

Published

2026-04-27

How to Cite

HORA, F. G. T.; BARBOSA, F. M.; CINTRA, B. B. Hyperbaric medicine as an adjunct treatment for fibromyalgia: an integrative review. JRG Journal of Academic Studies, Brasil, São Paulo, v. 9, n. 20, p. e093216, 2026. DOI: 10.55892/jrg.v9i20.3216. Disponível em: https://revistajrg.com/index.php/jrg/article/view/3216. Acesso em: 28 apr. 2026.

ARK