Clinical evaluation of neurological symptoms in professionals of health after Covid-19 infection in the city of Toledo – PR
DOI:
https://doi.org/10.5281/zenodo.8122288Keywords:
COVID-19, neurological symptoms, health professionals, headache, neurocovidAbstract
Introduction: The SARS-CoV-2 pandemic has infected more than 219 million people, generating socioeconomic, political and public health impacts worldwide. Neurocovid-19 is a variation that affects about a third of patients due to the tropism of the virus by the CNS and PNS, and can generate short and long-term damages in health professionals who work on the front line of the fight against the virus. Objective: to establish the neurological clinical changes after COVID-19 infection in health professionals in the UBS in the city of Toledo - PR. Methodology: exploratory and quantitative study carried out between August and October 2022, in 20 UBS in the city of Toledo - PR, through the application of self-completed questionnaires made in person and anonymously, previously approved by the Research Ethics Committee. Results and Discussion: In 131 research participants, 87 positive for COVID-19, a prevalence of neurological changes of 97.7% was observed, being higher in females (86%) and aged over 40 years (51%). The abstention rate was 67.65%. The highest prevalence of acute alterations was in taste (89.4%) and smell (85.4%). Among the manifestations observed in the long term, there is a higher prevalence of alteration in memory (90%), followed by alteration in reasoning (85%), vision (84.6%) and anxiety (84.5%). More than half of professionals had difficulty concentrating and associated memory loss. Final considerations: a high prevalence of neural symptoms after COVID-19 infection was found in health professionals. The main limitation of the study was the low adherence to research participation. The importance of further studies on acute and chronic neurological changes in this target population for the prevention of long-term complications is demonstrated.
Downloads
References
CIACCIO, Marcello et al. COVID-19 and Alzheimer’s Disease. Brain Sciences, v. 11, n. 3, p. 305, 2021.
CORONAVÍRUS (COVID-19). Google News. Disponível em: https://news.google.com/covid19/map?hl=pt-BR&gl=BR&ceid=BR%3Apt-419. Acesso em: 13 de nov. de 2021.
ELKIND, Mitchell SV et al. COVID-19: Neurologic complications and management of neurologic conditions. UpToDate, abr, 2021.
FERINI-STRAMBI, Luigi; SALSONE, Maria. COVID-19 and neurological disorders: are neurodegenerative or neuroimmunological diseases more vulnerable? Journal of neurology, p. 1-11, 2020.
FERRUCCI, Roberta et al. Long-lasting cognitive abnormalities after COVID-
Brain Sciences, v. 11, n. 2, p. 235, 2021.
FOTUHI, Majid et al. Neurobiology of COVID-19. Journal of Alzheimer's disease, n. Preprint, p. 1-17, 2020.
GKLINOS, Panagiotis. Neurological manifestations of COVID-19: a review of what we know so far. Journal of neurology, v. 267, p. 2485-2489, 2020.
GRAHAM, Edith L. et al. Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”. Annals of Clinical and Translational Neurology, 2021.
HELLMUTH, Joanna et al. Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients. Journal of NeuroVirology, v. 27, n. 1,
p. 191-195, 2021.
IPARDES. Caderno Estatístico: Município de Toledo. Instituto Paranaense de Desenvolvimento Econômico e Social. Disponível em: http://www.ipardes.pr.gov.br/Pagina/Cadernos-municipais. Acesso em: 13 de nov. de 2021.
KINGSTONE, Tom et al. Finding the'right'GP: a qualitative study of the experiences of people with long-COVID. BJGP open, v. 4, n. 5, 2020.
MARSHALL, Michael. How COVID-19 can damage the brain. Nature, v. 585,
n. 7825, p. 342-343, 2020.
MAURY, Alexandra et al. Neurological manifestations associated with SARS- CoV-2 and other coronaviruses: A narrative review for clinicians. Revue neurologique, 2020.
MUSSA, Bashair M.; SRIVASTAVA, Ankita; VERBERNE, Anthony JM. COVID-19 and Neurological Impairment: Hypothalamic Circuits and Beyond. Viruses, v. 13, n. 3, p. 498, 2021.
NAUGHTON, Sean X.; RAVAL, Urdhva; PASINETTI, Giulio M. Potential novel role of COVID-19 in Alzheimer’s disease and preventative mitigation strategies. Journal of Alzheimer's Disease, n. Preprint, p. 1-5, 2020.
NEJAD, Javad Hosseini et al. Neurological symptoms of COVID-19 infection; a cross-sectional study on hospitalized COVID-19 patients in Iran. Clinical Neurology and Neurosurgery, p. 106985, 2021.
ØSTERGAARD, Leif. SARS CoV‐2 related microvascular damage and symptoms during and after COVID‐19: Consequences of capillary transit‐time changes, tissue hypoxia and inflammation. Physiological reports, v. 9, n. 3,
p. e14726, 2021.
PIORE, Adam. "COVID-19 Could Increase Dementia, Other Brain Disorders for Decades to Come; A rise in strange neurological symptoms such as psychosis, tremors, extreme fatigue, phantom smells, dizziness, and 'brain fog' suggest that COVID-19 attacks the brain. The long-term implications are worrisome." Newsweek, vol. 176, no. 6, 19 Feb. 2021, p. NA. Gale Academic OneFile, link.gale.com/apps/doc/A653595933/AONE?u=capes&sid=AONE&xid=36fedb
Accessed 24 Apr. 2021.
PORTAL DA TRANSPARÊNCIA. Prefeitura de Toledo. Disponível em: https://www.toledo.pr.gov.br/pagina/portal-da-transparencia-contatos-saude. Acesso em: 13 de nov. de 2021.
RABBITT, Meghan. "Does Your Brain Feel Foggy? Being forgetful, unfocused, and mind-sluggish can be scary--but science shows that brain fog is super common, especially in these stressful times. Here's why, along with easy, research-backed ways to get back up to speed." Prevention, vol. 72, no. 12, Dec. 2020, p. 48+. Gale Academic OneFile, link.gale.com/apps/doc/A642568414/AONE?u=capes&sid=AONE&xid=8345e 8f4. Accessed 24 Apr. 2021.
RAHMAN, Mohammad Azizur et al. Neurobiochemical Cross-talk Between COVID-19 and Alzheimer’s Disease. Molecular Neurobiology, p. 1-7, 2020.
RITCHIE, Karen; CHAN, Dennis; WATERMEYER, Tam. The cognitive consequences of the COVID-19 epidemic: collateral damage?. Brain communications, v. 2, n. 2, p. fcaa069, 2020.
ROMERO-SÁNCHEZ, Carlos Manuel et al. Neurologic manifestations in hospitalized patients with COVID-19: the ALBACOVID registry. Neurology, v. 95, n. 8, p. e1060-e1070, 2020.
SATARKER, Sairaj; NAMPOOTHIRI, Madhavan. Involvement of the nervous system in COVID-19: The bell should toll in the brain. Life Sciences, p. 118568, 2020.
SHARIFIAN-DORCHE M, et al. Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic. J Neurol Sci. 2020.
TAGA, Arens; LAURIA, Giuseppe. COVID‐19 and the peripheral nervous system. A 2‐year review from the pandemic to the vaccine era. Journal of the Peripheral Nervous System, v. 27, n. 1, p. 4-30, 2022.
TANCHEVA, Lyubka et al. Emerging Neurological and Psychobiological Aspects of COVID-19 Infection. Brain Sciences, v. 10, n. 11, p. 852, 2020.
UR, Anoop; VERMA, Kavita. Happy Hypoxemia in COVID-19—A Neural Hypothesis. ACS chemical neuroscience, v. 11, n. 13, p. 1865-1867, 2020.
YACHOU, Yassine et al. Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients. Neurological Sciences, p. 1-13, 2020.
YANG, Fan et al. Manifestations and mechanisms of central nervous system damage caused by SARS-CoV-2. Brain Research Bulletin, 2021.
