Development of a formulation for topical use based on incremental innovation with active principle Ibuprofen

Abstract

This work proposes the development of a topical formulation containing Ibuprofen, as an alternative to oral anti-inflammatory drugs. Currently, systemic use of these medications can cause undesirable side effects, such as dizziness, nausea and gastrointestinal problems. Therefore, this incremental topical formulation seeks to reduce these side effects, avoiding the need for oral ingestion, reducing drug interactions and improving treatment adherence. The justification for the development of this formulation is based on the problems caused by the indiscriminate use of oral anti-inflammatories, which are being widely used without a medical prescription. Ibuprofen is an example of these medications, being used to relieve muscle pain and arthritis, reducing the production of prostaglandins associated with inflammation and pain. However, its oral use can lead to gastrointestinal complications and liver toxicity. Currently, there is no record of topical formulations of Ibuprofen in Brazil. Therefore, the objective of this research is to propose the development of an incremental topical formulation with the drug Ibuprofen.Pharmacotechnical studies and bench tests were carried out with 5 different formulations, to evaluate the viability and the best pharmaceutical form for this topical formulation. The research methodology was experimental, with market research, pharmacotechnical design, and analyzes of pH, viscosity, density, organoleptic characteristics and centrifugation test. As a result, a topical semi-solid product was obtained with a 5% Ibuprofen gel formulation, using a non-ionic gel with the thickener hydroxyethylcellulose, being an alternative to be considered as a substitute for the oral use of the active Ibuprofen and with high potential for a marketable drug. . The product remained stable and within the evaluated parameters and with satisfactory results for pH, viscosity, density, organoleptic characteristics and centrifugation test analyses.